I started with 9's.. LP type guitars, pointy ibanez, washburns, and even one Strat copy... I went to 10's when I switched to Tele's.. it was working great, but I thought I wanted to try something different, a small change to make my tele a bit different but something cheap, something reversible if I dont like it.. coincidentally it was time for a string change, went to the store, asked for 10's and saw 11-49's beside it, and thought why not.. I've put on 11's, never looked back.. ever since I've put 11's on everything.. Gretsches, Tele's, strats.. Havent tried with an LP or an ES335/Casino yet.. I dont have those guitars as of the moment.. but for sure I will put 11's on those guitars as well.. While Im not sure what it did to my tone, my ears arent picking up anything significant tone change, maybe bigger, more defined low E,A,D string tones? I did have an easier time tweaking amp and pedals EQ, maybe better bass response? Im not really sure, but the feel for me was better for me than slinky spaghetti strings.. I like my guitars to fight, 11's felt home and I stuck with it.. I havent tried 12's, I wanted to, but I dont want to redo all my set up.. Maybe if I will, I am eager to try 12's on a top loader affinity tele and see how I like it.. I play 12's on an acoustic.. no matter what scale length.. I think heavier gauges drive the acoustic guitar top harder, especially if its all solid.. thus I can feel it vibrating more and I can hear bigger tone than lighter strings.. harder to play, yes, especially the first time, but I got used to it.. bending is okay too, takes a little bit more effort than 10's but eventually it feels normal.. I doubt I'll go back to ligher strings..if anything Im wanting to try 11-52's or a hybrid set of 12-49's or 12-52's if there's such a string set.. but for now, I love 11-49s on strats, gretches and teles..