Yes, it will probably turn it into a portable barbeque.
(If the 2A fuse has already blown, anyway.)
Never EVER do this, for any reason. It will not get you out of a problem, it will just make things many times worse.
The chances are that the 2A fuse blew because of a relatively small fault, such as a blown tube or rectifier diode. If you now put a 10A fuse in, instead of the fuse blowing, it will probably be the power transformer and possibly other expensive components as well. You can easily turn a $50 repair into a $500 repair like this.
Don't even use a 3A fuse. The manufacturer chose the 2A one because it was the largest value that adequately protects the amp.