I've tried my Jubilees through my DRRI's Jensen C12K, Greenbacks, V30's, and CL80's. My 2554 combo has the stock V30 in it, but that speaker in the small cab gives a little too much of a middy/boxy sound IMO. Greenbacks give it more of a classic rock sound, which is nice but not as versatile IMO.
My 2553 is mostly used as a backup for either the DRRI, 2554, or Shiva 1x12 combo w/CL80; I like it best through the CL80. A nice blend of a V30 and a G12-75; nice bass and highs with more mids than the 75, but not too much like a V30.
I used to use a blackface style amp for gritty cleans and use pedals for dirt. This works and is a good sound, but in the end I ended up preferring the feel and tone of a channel switcher with a good lead channel. I play dirty the vast majority of the time.
For the longest time I would have considered myself a purest in the sense that I hated distortion/overdrive/crunch pedals and thought that only an amp's drive/lead channel could give me natural and organic tones- BUT, as I've grown more experienced I've realized that adding a pedal here and there can really help shape your tone and get you that much closer to the tone you're searching for. I guess for me it all depends on the amp I'm using at the time. As of right now I own a BBE Boosta Grande (clean boost) and an Xotic AC+. The clean boost really helps to fatten up my tone on my clean channels and pushes the amp a little harder to get some early break-up esp. at lower volumes when I don't want to be too loud. On the dirty channels I've found the boost to tighten up the lower to lower-mids and give the drive some for focus in those areas. My AC+ works good anywhere and by itself on the clean channel gives me a different overall drive flavor entirely different from the lead channel alone. The amps I use and have used are Two-Rock Type 3, CR Sig, Vox AC15H1TV, Orange Thunderverb/Rockerverb, Mesa Boogie Express/Mark IV..