If your loop has send and return controls so it will run at guitar level (not line level), or is designed to work at guitar level, it will work fine.
Here is my standard reply on the subject:
Most effects pedals do not work well in an amp's effects loop, unless
the loop has SEND and RETURN level controls. With those controls,
you can lower the signal to match what a stompbox expects to see.
If there are no controls, the loop is probably meant for line-level rack effects units.
If your loop does work well with effects pedals, the ones you
might want to put in the loop are delays and maybe other delay based
effects like reverb or chorus. Most other pedals will sound better before the