Yes, you can. I don't see any speaker emulation, but it has pre-amp emulation. It also has "recording out" which is what you would probably want to use. I cannot guarantee you would like it, but you can certainly do it. You might want to add a Tech21 speaker emulator.
The record out is speaker emulated. That is a trick for fuller sound by putting a dummie plug in the record out and it kicks it into the amp out. Better sounding.