It comes down to the output of the humbucker. A low output humbucker when split is very weak sounding and I don't think it sounds like a true strat in the #2 position. A medium to high output humbucker when split can get the "normal" single coil output and when blended in the #2 position it sounds just like a true Strat.
I have a George Lynch Screamin Demon in my Strat with some higher output "rock" wound single coils. The #2 position sounds like a true Strat. My favorite Strat humbucker!