I haven't tried this, but I thought bass speakers tried to do a more full range tone where guitar speakers are more colored. I've turned the speaker sim off of amp modeling pedals (and therefore, in theory, hearing what it sounds like through full range speakers) and the high end can get really fizzy with any distortion, but other than that it could be an ok tone.
Ya somewhat counter intuitive, but often bass speakers have too many highs for what youd want. Especially for overdriven guitars. Weve just built up a system where guitar speakers are meant to tame stuff starting 3 4 5k.
Wont hurt anything though if you want to try, unlike the other way around potentially.