I’m sure it would work but may not sound that great. You’d just have to try it. I had a Prism and used it into a Quilter, it doesn’t quiet impart enough “pre amp tone” imo, it’s more like a clean boost with treble and bass eq, so I think you’ll mostly miss having any control of mids or gain going into a power amp. The Kingsley Harlot and it’s siblings work great going straight into a power amp, also the Ethos pedals, Effectrode Blackbird... now those all impart some nice tones into a pwr amp. Imo the Prism is quite a few steps below those in terms of quality and tone.