Yes, my most practical amp is my Mark V. It's a fantastic amp. Just a s**tload of amp in one box. My favorite Mesa, so far. I just happen to have a couple of other amps that I go all googley-eyed over.If all of my stuff was lost or destroyed, and I only bought one amp to replace, I’d choose Mark IV.
It is not the amp I would sell last, because I have one other that has more sentimental value to me, but the Mark IV sounds the best and is most versatile across its three channels.