So here's where I'm at: newly gigging again, and I'm between pedalboards. I want to use my real amp, a Mesa Lonestar Special, and the guitar sounds for this band are heavily crafted Gilmour-type setups, not a 'pedal or two in the chain'. I will eventually create another giant spaceship pedalboard, but not in 2015. So the way to go for now is to use my HD500 - I can do crazy routing like in the studio, and I can set everything up on Exp pedals which are much more fun to work with than stomp switches (especially while singing!). I set everything up in standard 4CM - guitar to POD input, POD fx loop sends to my Amp input, then my Amp's loop sends to POD fx return, and finally POD output goes to Amp's fx return. Now I can put any effects before or after my Amp's preamp section. Good. After MUCH careful tweaking and A-B-ing, I got my dry guitar sound very very close to what it is without the POD inline. Really not bad! Unfortunately I like dual effect chains for true crazy studio routing, so that creates all kinds of drama with levels and extra effect blocks used up for summing the 2 paths etc. I got some advice from the awesome Sean Halley at Line 6, so I'll be sharing whatever he tells me. But if you guys have any thoughts on this, they are all much appreciated!