I just installed one in my Strat and I love it. It has a really sweet tone through a Fender tube amp and a darker tone through a Vox tube (as expected I suppose). I actually find myself using the neck and middle less and less.
A couple things to know though that might make me biased:
1. This is the first HSS setup I've had.
2. I prefer Les Pauls.
I have one in the bridge position of my Reverend Commando GT, which is a strat-like setup (paired with Lollar Vintage Blackface singles in neck and middle). I love it.