I am not sure why you'd use a looper if you were going straight into an amp. If your using effects pedals though it will sound better if you only route the signal through those being used at any one time, which is the point of a looper. So I guess I fail to see what point your trying to make in the context of using a pedalboard.To all loop switcher users: have you tried to record your guitar with all your pedals in a loop switcher, all bypassed, and then record the guitar straight into the amp? I think if you could do that you'd be very surprised with how good you guitar can sound without all those loopers and pedals between your guitar and an amp. Now this is difference! There is no buffer who could save the original guitar signal from degrading. Compensate - yes, but it won't be an original signal.