Being a little snarky I guess, but this is one of the reasons I sold mine. I'm pretty into stacking and couldn't get anything to sound right with my Blackstone. I sold it, bought a Honeybee, and haven't looked back.
The Blackstone was great with a really clean amp, but I changed my amp set up and the Blackstone just wasn't working with it.
jnepo1, do you run your Blackstone in front of everything? I'm going to try to see if I can find a spot for it on my main board. Right now, I take it when I'm doing a grab and go: I can always count on a good overdriven sound without fuss, but it seems like I've kept it in that role forever because I have so many other flavors of OD, distortion, and fuzz available on the big board (and too many sitting on the sidelines waiting for the occasional replacement of one of the front liners), and it's so good for that purpose...
I like it first in chain for the dynamics. But you should definitely try in after some other first pedals with and without the buffer engaged in the unit. I do like it after a fuzz pedal and with the buffer off.