Yes! RJM Mastermind PBC and other RJM Masterminds are programmable from your computer. I just purchased an RJM Mastermind GT10 to control my DPC-5 and DPC-8EZ (which I use together). Haven't posted much about that here as the RJM is really deep and I don't have much experience with it yet. But I'll share some of my experience for those who may be interested. And I want to gush a little bit . First off, I found the DPCs pretty easy to learn. Very easy to use with big box Strymons in particular. I found the learning curve is steeper on the RJM for bypassing the big Strymons...there are several ways to do it. The RJM has a lot of power and options in general, so you have to be prepared for that. However, RJM customer service is excellent and once I got started working from the computer editor, I was rolling smoothly. Many functions on the RJMs are pretty easy to understand and intuitive. Many things you can do just from the Mastermind, but the computer editor is really where it's at. You can use the RJM to control just the DPC-5, with loops and MIDI settings stored per DPC preset, or you can also have the RJM control the DPC-5 and MIDI separately (with DPC presets set to 'MIDI don't care'). In either case the RJM calls up program numbers to control the DPC-5. So Red Folder, Red Bank right most switch is program 1. One to the left is program 2, and so on. It will call up the analog loop combination and accompanying MIDI settings when you send a patch change. You do have to write down which program on the DPC-5 does what before you program. You know that your 'heavy overdrive' is program 1? Create a RJM preset that sends program 1 to the DPC. This is the hard part. Here's where the time saving comes in: all the RJM presets have actual names, you can literally call your preset 'Heavy Overdrive.' You will be able to see this in the RJM computer editor, on a PBC screen when the preset is selected, and on the button that activates it on the GT (button over every screen!). You can then make dummy/template copies of that preset and work from there. So you as long as you know 'Heavy Overdrive' is a certain sound, you don't have to remember the actual DPC program number from that point on. The same goes for Strymons or other MIDI devices, should you choose to program them according to RJM preset and not just DPC preset. You will likely need a chart of what each preset is, or at least some Preset Librarian screenshots. But with each RJM preset, you select the Strymon preset number you want for a particular device. You do not need to know MIDI CCs, and you can save time by creating dummy/template presets if you want to use a Strymon preset for more than one RJM preset. Other time saving things include song and setlist reorganization. Very easy on the RJMs. My issue with the DPCs was that anytime you want to rearrange presets, it can be lot of work. You were playing a song 1st in the set last week, now you're playing it 3rd, that's a lot of work. This only takes a few seconds. The downside to the RJM stuff is that it's expensive. An LCD screen over every button doesn't come cheap. It's worth it to me to not have to remember what I stored where though, and to have easy setlist, song, and preset reorganization. I think I'm in love.