Let me try to be as specific as I can with that broad question. I love Mayer's tone from his live album Try! with the John Mayer trio, his cleans, his overdriven tones, and just some of the cool effects on certain songs. I'm not sure what amps Mayer used for this album, and I definitely don't have access to a Dumble or a Two Rock. What I do have access to, are a 65 Reissue Deluxe Reverb with an eminence Cannabis Rex speaker in it, and a stock Blues Jr. I play a MIM strat, all stock pickups, with a humbucker in the bridge position. I wondered if anybody knew exactly what his rig consisted of, and any tips that anyone has discovered to nail his tone. I know, I know, most of it comes from his fingers....but there should be a way to come close. All my gear is shown in my signature. One of the songs that I really admire the tone of is Something's Missing. Mayer's guitar really has the wet, chimey sound...or maybe i'm not explaining that correctly. Anyways if anyone knows the answer to any of these questions i'd really appreciate it.