So I like to experiment with different ways to run my gear into my amps and I set up both of my main amps which are a Tremoverb Dual Rec with matching V30 cab and a Marshall DSL40c that also runs into that cab (independently). I decided to forego 4cm and set up the Helix to run directly to the return of both amps. I put pre-amp blocks in the path and matched as close as I could to the actual amp I.E. Cali Rectifire for my Dual Rec and Brit 2204 for the DSL and the results were nothing short of amazing. Compared to running 4cm in either amp the Helix produced the same general tones but with more clarity and dynamics than the actual amps themselves. I thought I was hearing things so I spent hours going back and forth meticulously making sure all the settings on the actual amps were the same on the Helix pre blocks. I did have to set the 1/4" out's differently on each amp, instrument for Marshall and Line for Mesa. After getting just the dirty pre blocks dialed in I added my typical go to things using the top path for pre-amp fx and gains and the bottom path for post amp fx and a clean boost. I like to do it this way to simplify things. I set up separate patches for each amp. For cleans I used Brit J-45 Nrm for the DSL and Cali IV Rhythm 1 for the Dual Rec. I cannot stop playing through my rig it sounds so good. The biggest kicker for me?.... I don't need to get the amps up the crazy volumes to sound good. Both the Marshall and Dual Rec needed to be very loud to sound and perform properly. Not any more BUT when I do decided to crank it they just sound even better instead of "ehh I can live with it". I'm sure I didn't stumble onto something that no one thought of but I wanted to share it. Running the Helix pre blocks into a power amp matching (or closely matching) the actual amp they modeled is the best of both worlds. On top of that no cable snake to run!