This question is like asking whats the best guitar to play. It's all personal choice and perception , I have no idea what you think a good fuzz would sound like. All you can do is look at what other people use as a guide only because as I've discovered with fuzz , it's not just the one element that gives you the sound you want. The circuit alone may work great with one type of pickup or guitar wiring or amp or other types of pedals. I use single coil most the time and I'm happy.
Good luck in your quest.
There is no correct answer for this. Different pickups will provide different sounds.
Think of the classic spaghetti western sounds and the psychedelic sounds from the 60s. Everyone from the Ventures to Jimi Hendrix.
In the late 60s and through the 70s you had a lot of people using fuzz with single coils (Page on Zep I, Gilmour on Dark Side of the Moon), and people using them with humbuckers too (Jeff Beck Group's Truth, Mick Ronson on Ziggy Stardust).
In more recent years, you've got the White Stripes (single coil that looks like a humbucker), and of course Smashing Pumpkins (Siamese Dream featured Fender strats with Blue/Silver/Red Lace Sensor single coil pickups, as well as Les Pauls with Humbuckers).
Through the years, players have tended to riff off the tones made by the players I've listed here. Each player does it differently, and gets different results. There is no perfect formula.
Cool, thanks for all that good info, but what about Corgan's new DiMarzio humbuckers in the bridge and neck positions?
Thanks for all that good information.
Here's a live video of Billy using his Strat with those DiMarzio's and a Big Muff.