why is a strat versatile? simple its featured everywhere, every genre has a legend playing a strat
obvious ones, funk, rock, blues, punk, country
other less obvious genres -
jazz : allan holdsworth had a strat era
shred guitar: yngwie
R&B: Nile ROdgers
metal : Iron Maiden
name any genre out there, theres one guy with a strat that made it big and is a legend in it. apart from tele, LP and the 335 (then again ive not seen anyone do metal on a 335) i think no other guitar brand in this world has such a presence
the other factor these days is that humbuckers now can be fitted into the ss slot pickup, which gives you humbucker tone but a SS configuration. so all you need is a screw driver and some soldering iron and you can mod your strat into something else.
try modding your 335 into a single coil guitar and see how had it is
In my OP, I'm pretty sure I made it clear that I had S/S/S Strats in mind. In Holdsworth's Just For The Curious book he makes it clear that he wasn't happy with the sound of the singles coils in the Strat and I'm pretty sure he modded it to be HH. And I'm not a fan of Iron Maiden but I don't think Dave Murray used purely S/S/S Strats most of the time.
I've done Black Metal inspired stuff on my 335. And I've never heard of anyone wanting to put a single coil in the bridge of a 335 so who cares if its really hard? Plenty of people mod S/S/S because (as you say) it isn't hard and because the S/S/S configuration is so unideal for so many things. The fact I've never heard anyone express the desire to put a single coil in the bridge of a 335 speaks volumes in my opinion.