I've found that with low or medium gain OD, I can back off volume a little and the clean sound I get is great. But with higher gain or stacked pedals, I have to roll back the guitar volume much more to clean up, and when I do, it's a little bad sounding (unnatural mids, woofy). So, although it might be ideal, I can't have one pedal set to high gain and then ride the volume all night; it's really only good down to 5 (on all my guitars). For this reason, I tend to ADD gain with more or higher gain pedals, rather than SUBTRACT from one pedal using my volume pot hwne using anything beyond medium gain. How far down do you turn the volume knob generally, and how far before your tone starts to be not so good? What's your approach?