my go-to OD pedal is my V2 Jekyll & Hyde pedal. It covers alot of ground between its 2 channels (hot-rodded TS-808 channel and a versatile distortion that goes from a slight boost to balls to the wall metal power).
My current settings get me a really tight JCM sound. I can't imagine ever finding a pedal that would replace it (maybe some to add to it, but never replace)
depends on the amp and the gig, primary guitar etc.
Many faves; all 5 of my Menatones with KK and KOTB the most fave, zendrive, klon, fuchs valve job, vintage tube driver, AM silver mod Boss OD (ts mod)..
I use an old TS-9 from 1993. Unmodified and I love it! Much more agressive than the 808. And cheaper too. Second choice is my OCD. really different flavour, but great none the less.
Tough to name a favorite, so many great pedals out there, but for light to medium OD, I'm gonna say Honey Bee. Wait, no, Klon. I use a Klon for more of a clean boost, and for what it does to the mids to bring your guitar forward in a mix. Can't be beat. Wait, no, Honey Bee. Crap, I can't decide....If I could only use one...Klon.... I think....