Stock settings, last in chain after Nova Repeater and MXR Carbon Copy. Haven't messed with anything becasue it sounds great. Should I? I'm not using it a boost, I just leave it on all the time.
Put it in the loop if possible. It sounded like ass in front of my with the distortion channel but good into a clean amp. In the loop it works great either way. Plug it in and leave it on.
I've tried it in and out of the loop, in front of a few different amps and with a few guitars with many different pedals and it didn't sound anything like ass in any situation.